In
vitro / In Vivo Anti-Arrhythmic Activity Based on the Vaughn-Williams
Classification
Presence or absence of anti-arrhythmic activity by specific mechanism
Anti Arrhythmia Results
The
chemical structures of 70 known anti-arrhythmic drugs were evaluated
by the CHEMSAS™
model with regard
to the presence or absence of specific activity according to the
Vaughn-Williams Classification. The Results are summarized in
Table 1 below.
Anti Arrhythmia Results
Class*
Sample N
Accuracy
Sensitivity
Specificity
PPV**
NPV***
Class 1
70
97.14%
100%
97.83%
95.83%
100%
Class 2
71
100%
100%
100%
100%
100%
Class 3
70
98.57%
90%
100%
100%
98.53%
Class 4
70
98.57%
88.89
100%
100%
98.39%
*The
Vaughn-Williams Classification of Anti-Arrhythmic Drugs
Class
1: Fast Sodium Channel Blocking drugs
Class
2: Beta Adrenergic Receptor Blocking drugs
Class
3: Potassium Channel Blocking drugs (prolong repolarization)
Class
4: Calcium Channel Blocking drugs
** PPV =
Positive Predictive Value -> the outcome is positive when
the model predicts it is positive
*** NPV
= Negative Predictive Value -> the outcome is negative when
the model predicts it is negative
